Understanding The Nicotinic Alpha3beta4 Receptor (P19243)

Target Name: Nicotinic alpha3beta4 Receptor

NCBI ID: P19243

Nicotinic alpha3beta4 Receptor

Other Name(s): alpha4beta2 receptor | Nicotinic alpha4beta2 receptor | alpha4beta2 nAChR

Understanding The Nicotinic Alpha3beta4 Receptor

The Nicotinic alpha3beta4 receptor (alpha4beta2 receptor), also known as the Muscarinic alpha4beta2 receptor, is a G protein-coupled receptor that plays a crucial role in various physiological processes in the body. It is a member of the Muscarinic receptor family, which includes over 20 different receptors that play a role in modulating neural and physiological processes. The alpha3beta4 receptor is one of the most well-studied Muscarinic receptors, and its function in neural circuits has led to its potential as a drug target.

The alpha3beta4 receptor is a transmembrane receptor that is located in the dopamine and norepinephrine nervous system. It is expressed in various tissues, including the brain, heart, and skeletal muscles. The receptor is involved in the regulation of a wide range of physiological processes, including sensory perception, neurotransmitter release, and muscle relaxation.

One of the key functions of the alpha3beta4 receptor is its role in modulating neurotransmitter release. The receptor is known to play a critical role in the regulation of dopamine release from the ventral tegmental area (VTA) of the midbrain. The VTA is a region of the brain that is responsible for the production and release of dopamine, which is a neurotransmitter that plays a crucial role in various aspects of neural circuits.

In addition to its role in modulating dopamine release, the alpha3beta4 receptor is also involved in the regulation of norepinephrine release. Norepinephrine is another neurotransmitter that is released from the VTA and is involved in the regulation of heart rate, blood pressure, and blood vessel diameter.

Another function of the alpha3beta4 receptor is its role in modulating pain perception. The receptor is known to play a critical role in the regulation of pain modulation, and is involved in the transmission of pain signals from the body to the brain.

The alpha3beta4 receptor is also involved in the regulation of muscle relaxation, which is an important aspect of muscle function. The receptor is known to play a critical role in the regulation of muscle tone and muscle contractions, and is involved in the control of muscle movement.

In addition to its role in modulating neural circuits, the alpha3beta4 receptor is also involved in the regulation of behavioral processes. The receptor is known to play a critical role in the regulation of anxiety and fear, and is involved in the transmission of these emotions from the brain to the body.

Despite its involvement in a wide range of physiological processes, the alpha3beta4 receptor is a relatively unstudied drug target. There are only a few compounds that have been shown to interact with the receptor, and more research is needed to fully understand its function and potential as a drug target.

In conclusion, the Nicotinic alpha3beta4 receptor is a G protein-coupled receptor that plays a crucial role in various physiological processes in the body. Its function in modulating neurotransmitter release, pain perception, and muscle relaxation makes it a potential drug target. Further research is needed to fully understand its function and potential as a drug target.

Protein Name: Nicotinic Alpha3beta4 Receptor

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